I did hand coding (with the help of CC's HTML Editor) for a number of years, but when it got to the point of needing a responsive site, I knew I wouldn't be hand coding that!
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Yes, I too had to spend some time wrapping my mind around how the layout should change at different screen sizes. I'm mostly happy with the layout I've done. My best advice would be to just try different things. Create test pages and then resize the browser window to see how things change and if you like the changes as the size gets smaller. You're not going to break the software by doing a lot of test pages. I figures out or stumbled upon more of what works (or doesn't work) by just trying things. If I over think things, then I get into trouble.
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