HELP - little folk that don't use photoshop and know all about pixels, etc. need to enlarge stuff without it getting all blurry and distorted. Would love to be able to enlarge a family picture and not lose quality - or enlarge clipart, etc.

These days it's all about size, ya know.

if you are using photoshop, just change the pixels under the "Image size" to 300. This will make your picture huge.
Then if you want to print it..it may keep it from getting too blurry and pixelated. If the original picture is already too small..then you probably wont be able to get around having it blurry. If its a standard picture size..like a 5' x 7' then this should work to blow it up.

Quality is going to suffer whenever you enlarge any raster graphic file (jpg, gifs, bmp, etc), no matter what program you use. Vector graphics is another story.