Hi Mike,
Websites living on S-Drive are no different than on any other server in most regards. Your HTML pages (including HTML5), CSS, JavaScript (using any framework like jQuery, YUI, etc.), and Flash files regardless of which app you used to make them will all function normally.
One major difference is that you can't execute custom scripts (like using PHP, ASP, RoR, etc.). This is for a variety of reasons, security being number one.
As for the safety and integrity of the server infrastructure, we are housed in a SAS 70 Type II and CICA 5970 certified facility with regulated climate control in accordance with
ASHRAE Guidelines, a 100% Power and Network Uptime guarantee, military-grade security, and it's staffed with engineers certified by Cisco, RedHat, MySQL, Microsoft, and others 24/7. It's the same facility used by local governments, and a good number of Fortune 100 companies.
Our cluster was designed with the help of high-level engineers from RedHat, MySQL, and Cisco, and is monitored constantly for errors and outages. A testament to this is that when our own website
struggled with the load of people hunting for eggs, S-Drive hosted sites were up and running without a glitch.
All that said, we think your site will be just fine.